Its effectiveness appears to be similar to other antidepressants and in terms of effect size has been described as modest. It may be used when other treatments have failed.

Vortioxetine is also used off-label for anxiety.

As of August 2021, vortioxetine remains in development for the treatment of anxiety disorders, binge-eating disorder, and bipolar disorder. It is in phase II clinical trials for these indications. There is also interest in vortioxetine for the potential treatment of social phobia, neuropathic pain, and for cognitive enhancement in major depression.

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