Medical organizations have found this combination to be safe and effective. Guidelines from the Royal College of Obstetricians and gynaecologists describe using mifepristone and misoprostol to be as effective and appropriate at any gestational age.
The World Health Organization and the American College of Obstetricians and Gynecologists recommend mifepristone followed by misoprostol for first- and second-trimester medical abortion.

Mifepristone alone is less effective, resulting in abortion within 1–2 weeks in anywhere from 54% to 92% of pregnancies, according to review of 13 studies.

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