It is used for short-term management of moderate to severe pain and is usually not prescribed for longer than five days, due to its potential to cause kidney damage. Ketorolac is used to treat idiopathic pericarditis, where it reduces inflammation.

It is effective when administered with paracetamol to control pain in newborns because it does not depress respiration as do opioids.

Ketorolac is also an adjuvant to opioid medications and improves pain relief and is also used to treat dysmenorrhea.

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