It is used in the control of the symptoms of:

• Acute psychosis, such as drug-induced psychosis caused by amphetamines, ketamine, and phencyclidine, and psychosis associated with high fever or metabolic disease. Some evidence has found haloperidol to worsen psychosis due to psilocybin
• Adjunctive treatment of alcohol and opioid withdrawal
• Agitation and confusion associated with cerebral sclerosis
• Alcohol-induced psychosis
• Hallucinations in alcohol withdrawal
• Hyperactive delirium (to control the agitation component of delirium)
• Hyperactivity, aggression
• Otherwise uncontrollable, severe behavioral disorders in children and adolescents
• Schizophrenia
• Therapeutic trial in personality disorders, such as borderline personality disorder
• Treatment of intractable hiccups
• Treatment of neurological disorders, including tic disorders such as Tourette syndrome, and chorea
• Treatment of severe nausea and emesis in postoperative and palliative care, especially for palliating adverse effects of radiation therapy and chemotherapy in oncology. Also used as a first line antiemetic for acute Cannabis Hyperemesis Syndrome

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