It can also be used for the treatment of chromomycosis (chromoblastomycosis), if susceptible strains cause the infection.
Flucytosine must not be used as a sole agent in life threatening fungal infections due to relatively weak antifungal effects and fast development of resistance, but rather in combination with amphotericin B and/or azole antifungals such as fluconazole or itraconazole.

Minor infections such as candidal cystitis may be treated with flucytosine alone.

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