It is a norepinephrine reuptake inhibitor and is believed to work by increasing norepinephrine and dopamine levels in the brain.

Atomoxetine is approved for use in children, adolescents, and adults. Its primary advantage over the standard stimulant treatments for ADHD is that it has little known abuse potential.

While it has been shown to significantly reduce inattentive and hyperactive symptoms, the responses were lower than the response to stimulants.
Its efficacy may be less than that of stimulant medications, there is some evidence that it may be used in combination with stimulants. Doctors may prescribe non-stimulants including atomoxetine when a person has bothersome side effects from stimulants; when a stimulant was not effective; in combination with a stimulant to increase effectiveness; or when there is concern about the abuse potential of psychostimulants in a patient with a history of drug use disorder.

Unlike α2 adrenoceptor agonists such as guanfacine and clonidine, atomoxetine’s use can be abruptly stopped without significant discontinuation effects being seen. The initial therapeutic effects of atomoxetine usually take 1 to 4 weeks to become apparent.

A further 2 to 4 weeks may be required for the full therapeutic effects to be seen. Incrementally increasing response may occur up to 1 year or longer. The maximum recommended total daily dose in children and adolescents over 70 kg and adults is 100mg.

There has been some suggestion that atomoxetine might be a helpful adjunct in people with major depression, particularly in cases with concomitant ADHD.

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It has no immediate anxiolytic effects, and hence has a delayed onset of action. Its full clinical effectiveness may require 2 to 4 weeks to manifest itself. The drug has been shown to be similarly effective in the treatment of generalized anxiety disorder (GAD) to benzodiazepines including diazepam, alprazolam, lorazepam, and clorazepate.
Buspirone is not known to be effective in the treatment of other anxiety disorders besides GAD, although there is some limited evidence that it may be useful in the treatment of social phobia as an adjunct to selective serotonin reuptake inhibitors (SSRIs).

There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual desire disorder (HSDD) in women.

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It has no immediate anxiolytic effects, and hence has a delayed onset of action. Its full clinical effectiveness may require 2 to 4 weeks to manifest itself. The drug has been shown to be similarly effective in the treatment of generalized anxiety disorder (GAD) to benzodiazepines including diazepam, alprazolam, lorazepam, and clorazepate.
Buspirone is not known to be effective in the treatment of other anxiety disorders besides GAD, although there is some limited evidence that it may be useful in the treatment of social phobia as an adjunct to selective serotonin reuptake inhibitors (SSRIs).

There is some evidence that buspirone on its own may be useful in the treatment of hypoactive sexual desire disorder (HSDD) in women.

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The recreational drug purple drank often contains a combination of promethazine with codeine containing cold medication.

It was once widely used as an antipsychotic, although it is generally not used for this purpose now. It has approximately 1 of 10 the antipsychotic strength of chlorpromazine. It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious.

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It also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder and other anxiety disorders.

Clonidine is also a mild sedative, and can be used as premedication before surgery or procedures.
Its epidural use for pain during heart attack, postoperative and intractable pain has also been studied extensively.

Clonidine can be used in

• restless legs syndrome
• to treat facial flushing and redness associated with rosacea
• as a treatment for diabetic neuropathy
• for migraine headaches and hot flashes associated with menopause
• to treat refractory diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, diarrhea associated with opioid withdrawal, intestinal failure, neuroendocrine tumors, and cholera
• in the treatment of Tourette syndrome (specifically for tics)

It has also had some success in clinical trials for helping to remove or ameliorate the symptoms of hallucinogen persisting perception disorder (HPPD).

Clonidine may be effective for lowering blood pressure in people with resistant hypertension.
It works by slowing the pulse rate and exerts a reduction of serum concentrations of renin, aldosterone and catecholamines.

Clonidine may be used to ease drug withdrawal symptoms associated with abruptly stopping the long-term use of opioids, alcohol, benzodiazepines and nicotine. It can alleviate opioid withdrawal symptoms by reducing the sympathetic nervous system response such as tachycardia and hypertension, hyperhidrosis (excessive sweating), hot and cold flashes, and akathisia. It may also be helpful in aiding smokers to quit.

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It is considered a first line drug for primary generalized tonic clonic seizures (includes simple partial, complex partial, and secondarily generalized seizures such as focal onset tonic clonic seizures). It is also used as an alternative or adjuvant medication for partial seizures, such as absence seizure, myoclonic seizure, and atonic seizures.

Lamotrigine is also approved for maintenance treatment of bipolar I disorder and bipolar II disorder. While the anticonvulsants carbamazepine and valproate are predominantly antimanics, lamotrigine has demonstrated efficacy only in preventing or reducing the risk of recurrent depressive episodes of bipolar disorder.

The drug seems ineffective in the treatment of current rapid cycling, acute mania, or acute depression in bipolar disorder.

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It also has several off-label uses, and has been prescribed to treat psychiatric disorders including stress, sleep disorders, and hyperarousal caused by post-traumatic stress disorder, borderline personality disorder and other anxiety disorders.

Clonidine is also a mild sedative, and can be used as premedication before surgery or procedures.
Its epidural use for pain during heart attack, postoperative and intractable pain has also been studied extensively.

Clonidine can be used in

• restless legs syndrome
• to treat facial flushing and redness associated with rosacea
• as a treatment for diabetic neuropathy
• for migraine headaches and hot flashes associated with menopause
• to treat refractory diarrhea associated with irritable bowel syndrome, fecal incontinence, diabetes, diarrhea associated with opioid withdrawal, intestinal failure, neuroendocrine tumors, and cholera
• in the treatment of Tourette syndrome (specifically for tics)

It has also had some success in clinical trials for helping to remove or ameliorate the symptoms of hallucinogen persisting perception disorder (HPPD).

Clonidine may be effective for lowering blood pressure in people with resistant hypertension.
It works by slowing the pulse rate and exerts a reduction of serum concentrations of renin, aldosterone and catecholamines.

Clonidine may be used to ease drug withdrawal symptoms associated with abruptly stopping the long-term use of opioids, alcohol, benzodiazepines and nicotine. It can alleviate opioid withdrawal symptoms by reducing the sympathetic nervous system response such as tachycardia and hypertension, hyperhidrosis (excessive sweating), hot and cold flashes, and akathisia. It may also be helpful in aiding smokers to quit.

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