The medication increases the number of satisfying sexual events. Flibanserin was originally developed as an antidepressant, before being repurposed for the treatment of HSDD.

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It acts as a monoamine oxidase inhibitor, and increases levels of monoamine neurotransmitters in the brain. At typical clinical doses used for Parkinsons disease, selegiline is a selective and irreversible inhibitor of monoamine oxidase B (MAO B), increasing levels of dopamine in the brain. In larger doses (more than 20 mg/day), it loses its specificity for MAO B and also inhibits MAO A, which increases serotonin and norepinephrine levels in the brain.

Selegiline has also been used off label as a palliative treatment for dementia in Alzheimers disease and is also used as a treatment for major depressive disorder.

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It is used to treat major depressive disorder, including atypical depression, especially when there is an anxiety component, typically as a second-line treatment. It is also used in depression that is not responsive to reuptake inhibitor antidepressants, such as the SSRIs, TCAs, or bupropion.

Tranylcypromine abuse has been reported at doses ranging from 120 to 600mg per day. It is thought that higher doses have more amphetamine like effects and abuse is promoted by the fast onset and short half life of tranylcypromine.

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There is tentative evidence that it may have fewer side effects than some other antidepressants. It works by stimulating melatonin receptors and blocking serotonin receptors.

No dosage tapering is needed on treatment discontinuation. Agomelatine has no abuse potential as measured in healthy volunteer studies.

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Use has only been studied up to 8 weeks. It may be less effective than venlafaxine, although some studies have found comparable efficacy with a lower rate of nausea. Doses of 50 to 400 mg/day appear effective for major depressive disorder.

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Its effectiveness appears to be similar to other antidepressants and in terms of effect size has been described as modest. It may be used when other treatments have failed.

Vortioxetine is also used off-label for anxiety.

As of August 2021, vortioxetine remains in development for the treatment of anxiety disorders, binge-eating disorder, and bipolar disorder. It is in phase II clinical trials for these indications. There is also interest in vortioxetine for the potential treatment of social phobia, neuropathic pain, and for cognitive enhancement in major depression.

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